ea0025p8 | Bone | SFEBES2011
Bassett J H Duncan
, Hernandez Rebecca
, Combs Charlotte
, Spek Anne van der
, Yu Ming
, Williams Allan
, Murphy Elaine
, Boyde Alan
, van Zeijl Clementine J J
, Boelen Anita
, Williams Graham R
Hypothyroidism and thyrotoxicosis have detrimental effects on skeletal development and adult bone strength. These effects result from thyroid hormone actions in bone, although a direct role for TSH in osteoblasts and osteoclasts was postulated following analysis of TSH receptor (TSHR) null mice. This hypothesis remains controversial as other studies failed to demonstrate osteoblast or osteoclast responses to TSH in vitro. Thyrostimulin is a heterodimeric glycoprotein ho...